How Long Does Vyvanse Stay In Your System

Vyvanse is a medication used to stimulate the central nervous system. It is made to change the chemicals in your brain in order to help with impulse control and hyperactivity. It is mainly used to treat ADHD in children older than six-years-old and in adults with the condition. If you’re concerned about the after effects of taking the drug including how long Vyvanse stays in your system and the side effects that go along with it, here you’ll find some basic information to help you find out about the medication.


What Is Vyvanse?

Also known as lisdexamfetamine, Vyvanse is a prescription medication that is most often issued to help manage ADHD but it is also known for treating binge eating disorders in adults. It works by positively affecting the nerves and chemicals in your brain in order to try and control your impulses and any hyperactivity that might be occurring.

Like most drugs that are meant to stimulate the central nervous system, this medication can be abused due to its addictive nature. You should only take the medication in the way prescribed by your doctor without taking more than recommended. Keep track of your medication so you can see whether or not anyone else is abusing the drug behind your back. The abuse of this medication can be serious and lead to severe problems and even death.

​In order to take the medication properly, it is recommended to take it in the morning either with or without food. You should avoid taking Vyvanse in the evening as it can cause insomnia and other sleep issues. Take the pill as a whole without crushing it, chewing it, or dividing it in any way. If you must, you can open the capsule and mix the medication into a liquid or yogurt as long as you consume the drink or yogurt immediately.

​While you’re taking this medication, you’ll need to be monitored regularly by your doctor in order to keep track of your heart rate and your blood pressure. It’s important to keep an eye on your vitals to make sure that the medication isn’t negatively affecting you.Vyvanse also has a high chance for overdosing due to its addictive nature and strength. Some of the overdose symptoms related to the drug are:

  • Muscle twitches
  • Confusion/lightheadedness
  • Panic
  • Hallucinations
  • Depression
  • Fatigue
  • Diarrhea/stomach pain
  • Restlessness
  • Tremors
  • Muscle weakness/pain/tenderness
  • Fainting/coma
  • Aggressiveness
  • Fever
  • General flu symptoms
  • Nausea/vomiting
  • Uneven heartbeats

There are also a number of side effects that go along with Vyvanse. If you have an allergic reaction to this medication, you may experience hives, trouble breathing, and swelling of the throat, tongue, and face. If you experience any of those or chest pains, breathing problems, heart problems, or other serious issues, stop taking the medication and contact your doctor immediately.

Some of the more common side effects of the medication are:

  • Weight loss/loss of appetite
  • Dry mouth
  • Insomnia
  • Dizziness
  • Irritability
  • Nausea/vomiting/diarrhea/stomach pain

The Half-life Of Vyvanse

Now that you know more about the drug, here is some information on how long Vyvanse stays in your system. When you take this medication, it converts to a d-amphetamine slowly in the body. This is the metabolite of the drug and is the active component in the medication which lasts in your system the longest.

The half-life, the amount of time it takes for half of the drug to leave your system, is one hour. This means that after four hours most of the Vyvanse will leave your system with only around 6 percent remaining in your body. While this sounds simple, it isn’t that easy. The d-amphetamine of the drug has a half-life of around 10 hours. This means that it takes around 40 hours for the majority of the metabolite to leave your system. While the drug is gone from your system completely in about 40 hours, the effects of the medication only last about 12 hours after you take it.

​If you are concerned about how long Vyvanse stays in your system because you are expecting to take a drug test, consider the different tests first. Vyvanse can be detected through the following tests:

1. Urine testing: after ingesting the drug, it can show up in your urine for as long as three days depending on your urinary pH. If you’ve been using the drug for a long period of time or if you’ve been taking more than necessary (abusing the drug) it may be in your system for longer.

2. Hair testing: sometimes, hair samples might be collected to see what drugs are in your system. Here, Vyvanse can’t be detected in hair follicles until a week or two after you take it.

3. Saliva testing: Vyvanse can usually be detected for up to days after you stop taking it for a saliva test. Chronic use of the medication may prolong the time the drug stays in your system, though.

4. Blood testing: this is an uncommon way to test for Vyvanse or amphetamines, in general as they have a narrow testing window. This drug can only be detected with this test within 24 hours after stopping the medication.

While all of the detection times for the various tests are different, individual factors can contribute to how long Vyvanse stays in your system. Things like you age, weight, other medical conditions/medications you take, and how long you’ve been taking Vyvanse can all play a role in how long the drug stays in your body.


Vyvanse, while widely abused and dangerous, can’t be detected by the various drug tests for very long. Hopefully, the information here regarding how long Vyvanse stays in your system along with the various pieces of information regarding the drug and its side effects. Please keep all of the side effects and overdose symptoms in mind while using this medication. If you are taking Vyvanse and are looking to stop taking it, it’s best to do so only under a doctor’s supervision and with their recommendation.

Anna Smith

Hi there ! I’m Anna Smith, chief editor at Healthankering. I'm a proud mother of three passionate about health tips, beauty and ways to live healthier with more energy ! We start Healthankering to provide advanced material about not only the best ways to get healthy, but also to entertain and create a great community. Welcome aboard !

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