How Long Does It Take For Diflucan To Work?

Diflucan, also known as fluconazole, is an antifungal medication that is prescribed to clear up vaginal yeast infections that are caused by Candida, a yeast that can grow out of control and cause infections. The medication is supposed to stop the growth of the yeast and allow your body to balance itself out. As yeast infections can be quite uncomfortable, you’re probably most interested in figuring out how long it takes for Diflucan to work.

Here, you’ll not only find out how long it takes for the medication to work but you’ll also get general information on the antifungal medication including side effects and some warnings to keep in mind.


What Is Diflucan?

Diflucan can come under different brand names as well as its prescription name, fluconazole. If you were prescribed this medication it’s most likely because you are dealing with vaginal candidiasis better known as a vaginal yeast infection. It can also be prescribed to treat other parts of the body that can be affected by candida including the mouth, blood, bladder, throat, lungs, and esophagus. More so, the antifungal can also be used to help people with a weak immune system prevent fungal infections from showing up in the first place.

Generally speaking, Diflucan is safe to use but you should avoid it if you’re allergic to fluconazole or any other antifungal medications (ketoconazole, itraconazole, voriconazole, posaconazole, and miconazole). Something else to consider is that the oral suspension of Diflucan contains sucrose which can harm you if you have problems with eating sugar or milk. You should also avoid Diflucan is you take cisapride or terfenadine

To avoid any issues, you should tell your doctor if you have any of the following:

  • Cancer
  • HIV or AIDS
  • Liver disease
  • Kidney disease

While a single dose of Diflucan at its normal 150mg is safe during pregnancy, you shouldn’t take more than one dose as long-term use of the drug can harm unborn babies. If you become pregnant during treatment with this drug, tell your doctor about your pregnancy to discuss your options. You should also stop taking it if you’re nursing as it can pass into your breast milk and harm your baby. Similarly, Diflucan can make your birth control medication less effective so you may have to use backup birth control methods while on this drug.

If your doctor prescribes a stronger or weaker dose than the typical 150mg it might be because of your body weight, because you take other medications, or because of pre-existing medical conditions. Make sure you follow all of your doctor’s instructions while taking Diflucan.

When not taking the medication, store it at room temperature and make sure it is away from children who may ingest it by mistake. If you need to dispose of the medication for any reason, do not put it down the sink or flush it down the toilet. Instead, reach out to your local pharmacy and ask about the best ways to dispose of leftover medications.

Diflucan is fairly safe when taken properly, but like any medication, there can be side effects. Some may be easy to manage on your own and should go away over time, but if you are having any issue for a prolonged period of time, contact your doctor immediately. 

Some of the side effects for Diflucan are:

  • Diarrhea
  • Stomach pain
  • Headaches
  • Vomiting
  • Dark urine
  • Nausea
  • Loss of appetite
  • Weight loss
  • Jaundice
  • Pale stools

Allergic reaction symptoms may also occur. If that happens, you must contact a doctor right away. Those symptoms are:

  • Cramps
  • Difficulty breathing
  • Swelling of the face, tongue or throat
  • Blistering skin
  • Peeling skin
  • Large rashes

While taking Diflucan, you should avoid drinking grapefruit juice as the juice can cause the medication to build up too much in your body and cause harmful side effects. You should also avoid sexual intercourse as you can pass on the yeast infection to your partner.

How Long Does It Take For Diflucan To Work

When trying to see how long it takes for Diflucan to work, take the typical dose into consideration. Diflucan, when prescribed in 150mg oral capsules, should start to work within one day of taking the medication but it can take as long as three to seven days for the infection to clear up and for symptoms to improve. If your yeast infection doesn’t clear up after seven days, you have to contact your doctor as there may be another problem causing your symptoms. If the drug is being used by men to clear up a yeast infection in the tip of the penis, it can take about eight days for Diflucan to clear up the infection.

Specifically, in a study done on eight women who were given Diflucan for vaginal yeast infections, the medicine cleared the infection in two women within 24 hours while the remaining six women were fungal infection free after three days of taking the medication at 150mg. all patients reported that they were symptom-free at the end of the research study.

While Diflucan can work rather fast in some women when it comes to treating vaginal yeast infections, there are reports that say 20 percent of women who get rid of their infection with this drug get another infection in about a month’s time. About 90 percent of the drug will be absorbed into the body, however, so you have some protection for about a week after taking the medication as it takes about seven days to completely pass through your system.


Now that you know how long it takes for Diflucan to work, you can feel perfectly comfortable taking it to clear up your yeast infection. Remember to disclose all of your medical history including current medications and supplements as well as pre-existing conditions and your family history (especially related to Long QT Syndrome).

Take the medication as prescribed and do not increase or decrease the dosage or stop taking the medication early without specific instructions from your doctor. If your condition doesn’t improve, you experience severe side effects, or if your condition changes while on Diflucan, contact your doctor as soon as possible.

Anna Smith

Hi there ! I’m Anna Smith, chief editor at Healthankering. I'm a proud mother of three passionate about health tips, beauty and ways to live healthier with more energy ! We start Healthankering to provide advanced material about not only the best ways to get healthy, but also to entertain and create a great community. Welcome aboard !

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